![]() ![]() Furthermore, using live-labeling techniques, we confirmed co-transfection with mutant PRRT2 caused an increase in GRIA1 distribution on the cell surface. Our co-immunoprecipitation assays reveal mutant PRRT2 interferes with SNAP25 and GRIA1 interactions, respectively. Using double immunostaining assays we confirm Prrt2 is located at the glutamatergic neurons in accordance with its function. Here, we reveal higher levels of glutamate in the plasma of PKC patients and the culture medium of neurons following knock-out Prrt2 expression. However, as little is known about the function of PRRT2, elucidating its function will benefit not only PKC studies, but also many other related disorders. ![]() We previously identified PRRT2 as the causative gene of PKC. Paroxysmal kinesigenic choreoathetosis (PKC) is an inherited disease of the nervous system.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |